![]() Unable to pursue a military career because of his condition, Leopold enrolled in the Christ Church, Oxford University, where he studied a wide variety of subjects. ![]() Victoria thought it was unnecessary for him to leave the home and even encouraged him not to marry or have children. He was followed in permanent attendance by several physicians. The condition caused Victoria much anxiety, prompting her to keep the prince close to her side. Of four sons, he was the only one with hemophilia. Leopold, Victoria’s eighth of nine children, was born at Buckingham Palace. The following is an account of The Royal Disease as found in some of the major ruling monarchies of Europe. Though great care was taken to protect the princes, unfortunately, many did not live to see adulthood. At a time when doctors knew little about the condition, there was not much a family could do for their affected children. Though they lived lavish courtly lifestyles, life for Victoria’s descendants with hemophilia was not easy. The line of princes with hemophilia in Europe led to the bleeding disorder being coined as The Royal Disease. As carrier of hemophilia, Queen Victoria inadvertently spread the condition from the United Kingdom to the royal houses of Germany, Spain, and Russia. It was through these marriages that Victoria not only secured political clout, but such practice was also the cause for the passing of a condition the royal monarchy often tried to hide, hemophilia. Queen Victoria became known as The Grandmother of Europe as some of her nine children and 42 grandchildren married into royal families across the continent. One way the monarchy sought to secure political alliances came through strategic marriages between the ruling royal families. Under Victoria, the British Empire rose to become a leading global power. Taking the throne at age of eighteen and ruling for sixty-four years, Queen Victoria is perhaps one of the most iconic figures in the history of the British monarchy. From industry and science to culture and politics, her rule ushered in an era that would later bear her name, Victoria. Her sovereignty entered a time that saw progress and growth in nearly every aspect of society. Following a scientific approach combining current genetic experimentation tools and the development of biological information technology, researchers were able to identify each body, allowing them to obtain precious genetic material from the young Czar Alexis, who was stricken by the disease, which revealed a causal substitution in the splice acceptor site of exon 4 in the F9 gene.Until the reign of modern-day Queen Elizabeth, Queen Victoria had the longest reign of any female monarch in history. A second tomb was discovered in 2007, allowing Russian and American scientists to fill in this gap in medical history. In 1991, a tomb containing the remains of Czar Nicolas II's entire family was discovered. ![]() Because of this, the characterization of haemophilia (deficit of either factor VIII or XI) and the identification of the causal mutation are rendered impossible. Today, none of Queen Victoria's living descendents carry haemophilia. Haemophilia is an illustration of this, as this congenital hereditary coagulation disorder, passed through the majority of royal European families at the beginning of the 20th century by Queen Victoria of England and Empress of the Indies, had indisputable political consequences, which led to one of the most defining moments of contemporary history: the Bolshevik Revolution. And blood can change the course of history'.
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